Abstract |
An inhibitor of cholesterol synthesis, AY 9944 (trans-1,4-bis(2-chlorobenzylaminomethyl) cyclohexane dihydrochloride) is teratogenic. A single dose of AY 9944 (50 mg/kg or 75 mg/kg) given to Wistar pregnant rats on the second, fourth, sixth, seventh, or eighth day of gestation induced malformations such as holoprosencephaly. They were often limited to isolated pituitary agenesis. The highest percentage of holoprosencephalic fetuses was found when AY 9944 was given on the fourth day of gestation. Whatever the dose and the day of administration, the lower the maternal plasma cholesterol level, the more frequent were holoprosencephalic fetuses. Therefore, it is suggested that the decrease in maternal plasma cholesterol level is at least one of the factors provoking holoprosencephaly.
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Authors | V Barbu, C Roux, R Dupuis, J Gardette, J C Maziere |
Journal | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
(Proc Soc Exp Biol Med)
Vol. 176
Issue 1
Pg. 54-9
(May 1984)
ISSN: 0037-9727 [Print] United States |
PMID | 6200888
(Publication Type: Journal Article)
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Chemical References |
- Cyclohexanes
- Teratogens
- trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
- Cholesterol
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Topics |
- Abnormalities, Drug-Induced
(etiology)
- Animals
- Cholesterol
(blood)
- Cyclohexanes
(adverse effects)
- Female
- Fetal Death
(chemically induced)
- Gestational Age
- Head
(abnormalities)
- Pregnancy
- Rats
- Rats, Inbred Strains
- Teratogens
(pharmacology)
- trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
(adverse effects)
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