[Effect of kontrikal on the kinin system of the lymph and blood in anaphylactic shock].

Abstract

A study was made of the effect of contrykal, a nonspecific inhibitor of the trypsin-plasmin-kallikrein system on the time course of kininogens and free kinins in the lymph of the thoracic duct and blood. Experiments were performed on 42 guinea-pigs with anaphylactic shock. It was demonstrated that anaphylactic shock was accompanied by the activation of the blood and lymph kinin system, manifesting in a decrease in the bradykininogen level and a rise in the content of free kinins in both body fluids. Pretreatment with contrykal did not avert the development of anaphylactic shock but significantly reduced the pronounced manifestations of the clinical picture and exerted an inhibitory action on the activation of the kallikrein-kinin system of the blood and lymph.

• Authors: M M Minnebaev, F I Mukhutdinova, M S Musin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1984 Jan-Feb Vol. 47 Issue 1 Pg. 77-81 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie kontrikala na kininovuiu sistemu limfy i krovi pri anafilakticheskom shoke.
• PMID: 6200359 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Free Radicals
• Kininogens
• Kinins
• Aprotinin

Topics

• Anaphylaxis (drug therapy, metabolism)
• Animals
• Aprotinin (therapeutic use)
• Drug Evaluation, Preclinical
• Free Radicals
• Guinea Pigs
• Kininogens (metabolism)
• Kinins (metabolism)
• Lymph (drug effects, metabolism)
• Thoracic Duct
• Time Factors
• Veins