Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4?

Abstract

Twenty-one Israeli Jewish pemphigus vulgaris (PV) patients were studied for the HLA-D lymphocyte defined determinants and the serologically defined antigens of the HLA-A, B, and DR series. HLA-D typing revealed that Dw10 is significantly associated with PV: 86% of patients vs 18% of controls carried Dw10, and DR4 was present in 86% of patients as compared to 38% in the controls. The most striking observation was that all Dw10 positive patients were also positive for DR4, and no other patient carried DR4 alone. The relative risk for a Dw10-DR4 carrier to develop PV was estimated at 31.9, higher than that observed for Dw10 alone (RR 26.7) or DR4 alone (RR 9.6). Probably HLA-Dw10 predisposes for pemphigus vulgaris.

• Authors: A Amar, N Rubinstein, S Hacham-Zadeh, O Cohen, T Cohen, C Brautbar
• Journal: Tissue antigens (Tissue Antigens) Vol. 23 Issue 1 Pg. 17-22 (Jan 1984) ISSN: 0001-2815 [Print] England
• PMID: 6199866 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epitopes
• HLA Antigens
• HLA-D Antigens
• HLA-DR Antigens
• HLA-DR4 Antigen
• HLA-DRB1 Chains
• HLA-DRB1*04:02 antigen
• Histocompatibility Antigens Class II

Topics

• Epitopes (analysis)
• Female
• HLA Antigens (genetics)
• HLA-D Antigens
• HLA-DR Antigens
• HLA-DR4 Antigen
• HLA-DRB1 Chains
• Histocompatibility Antigens Class II (genetics)
• Humans
• Jews
• Lymphocytes (immunology)
• Male
• Pemphigus (genetics, immunology)