Abstract |
The effect of systemic administration of guanosine, cGMP, dipalmitoyl ( dp) cGMP, 5'GMP and 5' GDP on lordosis behavior was studied in ovariectomized, estradiol benzoate (EB) primed rats (4 micrograms/rat). EB per se induced only weak lordosis behavior. Free cGMP (2.0 mg/rat); dp cGMP (1.0, 2.0 and 4.0 mg/rat) and 5'GMP (2.0 and 4.0 mg/rat) induced significant lordosis behavior in ovariectomized, estrogen-primed rats. Dp cGMP and 5'GMP (2.0 mg/rat), also induced lordosis behavior in ovariectomized, adrenalectomized estrogen primed rats. Lordosis behavior elicited with 2.0 mg/rat dp cGMP was blocked with 8.0 mg/rat methyl-isobutylxanthine (MIX), a phosphodiesterase inhibitor, suggesting that dp cGMP stimulated lordosis through its conversion to 5'GMP. Results are interpreted in terms of the activation of adenylate cyclase-cAMP systems by guanine nucleotides.
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Authors | A Fernández-Guasti, G Rodríguez-Manzo, C Beyer |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 31
Issue 5
Pg. 589-92
(Nov 1983)
ISSN: 0031-9384 [Print] United States |
PMID | 6198669
(Publication Type: Journal Article)
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Chemical References |
- Guanosine
- Guanosine Diphosphate
- Estradiol
- Guanine
- Guanosine Monophosphate
- Cyclic GMP
- 1-Methyl-3-isobutylxanthine
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Topics |
- 1-Methyl-3-isobutylxanthine
(pharmacology)
- Animals
- Castration
- Cyclic GMP
(pharmacology)
- Estradiol
(pharmacology)
- Female
- Guanine
(analogs & derivatives)
- Guanosine
(pharmacology)
- Guanosine Diphosphate
(pharmacology)
- Guanosine Monophosphate
(pharmacology)
- Rats
- Rats, Inbred Strains
- Sexual Behavior, Animal
(drug effects)
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