Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.

Kynurenine, tryptophan and 5-hydroxyindoleacetic acid were measured in human lumbar and cisternal cerebrospinal fluid (CSF) taken during pneumoencephalography. The results do not support the hypothesis that any substantial part of the CSF kynurenine is of central origin. However, the results suggest that CSF kynurenine is reduced in some epileptic subjects and this seems to be due to the disease rather than anticonvulsants. This finding is of interest in view of the reported convulsant effect of kynurenine in experimental animals.
AuthorsS N Young, M H Joseph, S Gauthier
JournalJournal of neural transmission (J Neural Transm) Vol. 58 Issue 3-4 Pg. 193-204 ( 1983) AUSTRIA
PMID6198458 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amino Acids
  • Anticonvulsants
  • Kynurenine
  • Hydroxyindoleacetic Acid
  • Tryptophan
  • Adolescent
  • Adult
  • Aged
  • Amino Acids (cerebrospinal fluid)
  • Anticonvulsants (therapeutic use)
  • Epilepsy (cerebrospinal fluid, drug therapy)
  • Epilepsy, Temporal Lobe (cerebrospinal fluid)
  • Humans
  • Hydroxyindoleacetic Acid (cerebrospinal fluid)
  • Kynurenine (cerebrospinal fluid)
  • Middle Aged
  • Tryptophan (cerebrospinal fluid)

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