Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis. Preferential relationship with HLA-Dw rather than HLA-DR specificities.

Abstract

Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. Dw4 and DR4 were strongly associated with severity of erosions when analysis was restricted to each of the following: patients with erosions, those under 50 at onset, and all females. Relationships were consistently stronger with Dw4 than with DR4. Another D-related specificity, MT3, was positively correlated and Dw2/DR2 negatively correlated with erosions.

• Authors: A Young, D Jaraquemada, J Awad, H Festenstein, M Corbett, F C Hay, I M Roitt
• Journal: Arthritis and rheumatism (Arthritis Rheum) Vol. 27 Issue 1 Pg. 20-5 (Jan 1984) ISSN: 0004-3591 [Print] United States
• PMID: 6197976 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Epitopes
• HLA-DR Antigens
• HLA-DR2 Antigen
• Histocompatibility Antigens Class II

Topics

• Age Factors
• Arthritis, Rheumatoid (diagnostic imaging, immunology)
• Epitopes
• Female
• HLA-DR Antigens
• HLA-DR2 Antigen
• Histocompatibility Antigens Class II (analysis)
• Histocompatibility Testing
• Humans
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Radiography
• Sex Factors