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Investigation of the effect of cellular and viral nucleic acids against experimental influenza virus A/PR8/34 (H1N1) infection in mice.

Abstract
Treatment of mice with different cellular nucleic acids prior to inoculation of influenza virus A/PR8/34 (H1N1) conferred--in some cases--a nonspecific protection against the experimental infection. The optimal amount of nucleic acid was 400 micrograms/mouse, irrespective of the origin or type of the macromolecule.
AuthorsR Repanovici, I Moisa, O Mihalache, I Iacobescu, O Burducea, R Iliescu, L M Popa, N Cajal
JournalVirologie (Virologie) 1983 Jul-Sep Vol. 34 Issue 3 Pg. 183-9 ISSN: 0253-181X [Print] Romania
PMID6195810 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • RNA, Viral
  • RNA
  • DNA
  • RNA, Transfer
Topics
  • Animals
  • Cell Line
  • Chick Embryo
  • DNA (pharmacology)
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza A virus
  • Liver (analysis)
  • Mice
  • Orthomyxoviridae Infections (prevention & control)
  • RNA (pharmacology)
  • RNA, Transfer (pharmacology)
  • RNA, Viral (pharmacology)
  • Spleen (analysis)
  • Time Factors

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