Endogenous myelin basic protein-serum factors (MBP-SFS) and anti-MBP antibodies in a patient with post-herpes simplex virus acute disseminated encephalomyelitis.

Abstract

The measurement of myelin basic protein serum factors (MBP-SFs) and anti-MBP antibodies in specimens from a patient with post-herpes simplex acute disseminated encephalomyelitis (ADE) is described. Transitory appearance of high affinity anti-MBP antibodies in the absence of detectable MBP-SFs was observed. This pattern was similar to that found previously in acute multiple sclerosis and experimental allergic encephalomyelitis. These findings are consistent with the hypothesis that a possible normal role of MBP-SFs is as neuroautotolerogens, preventing autoreactive lymphocyte clones from damaging myelin.

• Authors: S G Rabinowitz, E D Day, P Y Paterson, H Koenig
• Journal: Journal of the neurological sciences (J Neurol Sci) 1983 Aug-Sep Vol. 60 Issue 3 Pg. 393-400 ISSN: 0022-510X [Print] Netherlands
• PMID: 6195314 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antibodies
• Blood Proteins
• Myelin Basic Protein
• myelin basic protein-serum factors

Topics

• Acute Disease
• Adult
• Antibodies (analysis, cerebrospinal fluid)
• Antibody Affinity
• Blood Proteins (cerebrospinal fluid)
• Encephalomyelitis (blood, cerebrospinal fluid, etiology, immunology)
• Herpes Simplex (complications)
• Humans
• Male
• Myelin Basic Protein (immunology)
• Radioimmunoassay