Abstract |
Irritation and staining, the side effects of dithranol and related compounds have previously been studied after a single chamber-exposure. To mimic the therapeutic situation, the chamber application was repeated for 3 weeks on the uninvolved back skin of 17 psoriasis patients. In equimolar concentrations corresponding to 0.05% dithranol, dithranol caused markedly more erythema and staining than 10-propionyl dithranol and 10-butyryl dithranol, whereas 10-butyryl dithranol irritated and stained less than 10-propionyl dithranol. To reach the irritation and staining level of dithranol, a 4-fold higher concentration of 10-butyryl dithranol was required. During the first week the irritation culminated, declining later despite repeated applications, possibly because of exhaustion of anthrone-induced inflammatory mediators.
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Authors | H Brandt, K K Mustakallio |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 63
Issue 3
Pg. 237-40
( 1983)
ISSN: 0001-5555 [Print] Sweden |
PMID | 6192640
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthracenes
- Irritants
- 10-propionyl dithranol
- butantrone
- Anthralin
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Topics |
- Anthracenes
(adverse effects)
- Anthralin
(administration & dosage, adverse effects, analogs & derivatives)
- Erythema
(chemically induced)
- Humans
- Irritants
(adverse effects)
- Skin
(drug effects)
- Skin Tests
(methods)
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