The influence of limonene on induced delayed hypersensitivity to citral in guinea pigs. II. Label distribution in the skin of 14C-labelled citral.

Abstract

14C-labelled citral was applied on four groups of guinea pigs: (a) one sensitized to citral alone; (b) one sensitized to a citral-d-limonene 1 : 1 molar mixture; (c) FCA-treated controls; (d) controls. The most important results concern the amount of labelled material in soluble compared with insoluble skin protein extracts (SPE). In citral-sensitized animals, more label was found in the soluble SPE when citral + limonene was applied to the skin; in citral + limonene sensitized animals, the same trend (i.e. more label in soluble SPE) was found. The possible role of limonene in alleviating the allergic reaction to citral is discussed.

• Authors: P Barbier, C Benezra
• Journal: Acta dermato-venereologica (Acta Derm Venereol) Vol. 63 Issue 2 Pg. 93-6 ( 1983) ISSN: 0001-5555 [Print] Sweden
• PMID: 6189349 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acyclic Monoterpenes
• Carbon Radioisotopes
• Cyclohexenes
• Monoterpenes
• Terpenes
• Vitamin A
• Limonene
• citral

Topics

• Acyclic Monoterpenes
• Animals
• Carbon Radioisotopes
• Cyclohexenes
• Feces (analysis)
• Female
• Guinea Pigs
• Hypersensitivity, Delayed (chemically induced)
• Limonene
• Monoterpenes
• Skin (metabolism)
• Terpenes (adverse effects, analysis, pharmacology, urine)
• Tissue Distribution
• Vitamin A (antagonists & inhibitors)