VAB-6 combination chemotherapy in resected stage II-B testis cancer.

Abstract

Twenty-four patients with resected Stage II-B nonseminomatous germ cell tumors of the testis received adjuvant chemotherapy with the modified VAB-6 regimen for one year. Eighteen patients had nodal category N2B and six nodal category N3 (extranodal extension of tumor). Adjuvant VAB-6 started with two four day inductions at approximately four week intervals. Induction was cyclophosphamide 600 mg/m2 IV, vinblastine 4 mg/m2 IV, dactinomycin 1 mg/m2 IV, bleomycin 30 mg IV on day 1, then bleomycin 20 mg/m2/day by continuous 24 hour infusion for three days, and cis-platinum 120 mg/m2 IV on day 4. Maintenance was vinblastine 6 mg/m2 IV and dactinomycin 1 mg/m2 IV every three weeks. Six patients received a third induction but without bleomycin. All 24 patients remain free of disease with a median follow up of 24 months. Myelosuppression was the major toxicity. Four patients received antibiotics for fever during myelosuppression. In one patient, serum creatinine temporarily rose over 2 mg/dl after cis-platinum. VAB-6 is effective in the prevention of recurrences in resected Stage II-B nonseminomatous germ cell tumors. However, the optimal regimen remains to be defined.

• Authors: D Vugrin, W F Whitmore Jr, H W Herr, P Sogani, R B Golbey
• Journal: Cancer (Cancer) Vol. 51 Issue 1 Pg. 5-8 (Jan 01 1983) ISSN: 0008-543X [Print] United States
• PMID: 6185195 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Bleomycin
• Chlorambucil
• Dactinomycin
• Vinblastine
• Doxorubicin
• Cyclophosphamide
• Cisplatin

Topics

• Adolescent
• Adult
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols
• Bleomycin (administration & dosage, therapeutic use)
• Chlorambucil (therapeutic use)
• Cisplatin (administration & dosage, therapeutic use)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Dactinomycin (administration & dosage, therapeutic use)
• Doxorubicin (therapeutic use)
• Drug Administration Schedule
• Drug Therapy, Combination
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Neoplasms, Germ Cell and Embryonal (drug therapy, surgery)
• Testicular Neoplasms (drug therapy, surgery)
• Vinblastine (administration & dosage, therapeutic use)