[Physicochemical and immunochemical properties of heavy chains of immunoglobulin G typical of malignant growth].

Abstract

Molecular weight of heavy chains of immunoglobulin G typical of cancer is studied immunoglobulin and may be responsible for manifestation of certain anomalous acid and peptide composition of this protein heavy chains as compared with immunoglobulin G in blood serum of healthy people. Immunochemical methods helped detecting an antigenic determinant (or determinants) which is arranged in the heavy chains of the studied immunoglobulin and may be responsible for manifestation of certain anomalous properties of cancer-typical immunoglobulin G molecules. A set of bromo-cyanogenic fragments differing from the spectrum of these fragments in the heavy chains of normal immunoglobulin G is formed following a specific chemical effect of bromo-cyanogen on the heavy chains of immunoglobulin G typical of cancer. Essential differences are found in dancyl-fingerprints of the heavy chains of the compared proteins. Everything mentioned is a result of changes in the primary structure of the heavy chains of immunoglobulin G typical of cancer.

• Authors: L N Sen'ko, B A Protsenko, V P Korotkoruchko
• Journal: Ukrainskii biokhimicheskii zhurnal (1978) (Ukr Biokhim Zh (1978)) 1982 May-Jun Vol. 54 Issue 3 Pg. 243-8 ISSN: 0201-8470 [Print] Ukraine
• Vernacular Title: Fiziko-khimicheskie i immunokhimicheskie osobennosti tiazhelykh tsepeĭ immunoglobulina G, kharakterno dlia zlokachestvennogo rosta.
• PMID: 6179280 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Epitopes
• Immunoglobulin G
• Immunoglobulin Heavy Chains
• Peptide Fragments
• Cyanogen Bromide

Topics

• Amino Acids (analysis)
• Cyanogen Bromide
• Epitopes (analysis)
• Humans
• Immunoglobulin G (isolation & purification)
• Immunoglobulin Heavy Chains (isolation & purification)
• Neoplasms (immunology)
• Peptide Fragments (analysis)