The use of an antihistamine-decongestant in conjunction with an anti-infective drug in the treatment of acute otitis media.

Abstract	We evaluated the efficacy of an antihistamine-decongestant combination as adjunctive therapy in the treatment of acute otitis media with effusion. In a randomized study, 53 children were treated for acute otitis media with antibiotics and either Naldecon or placebo. Subjects were evaluated by tympanometry and pneumotoscopy. Follow-up evaluation was performed at days seven and 14 of therapy. The antihistamine-decongestant prescription was found to influence both the duration of nasal congestion and the course of middle ear effusion: Naldecon-treated subjects were symptomatic with nasal congestion for an average of six days compared to nine days reported by those given placebo, and the risk of persisting middle ear effusion was approximately two times greater in the placebo-treated group when evaluated by tympanometry.
Authors	D M Moran, K D Mutchie, M D Higbee, L D Paul
Journal	The Journal of pediatrics (J Pediatr) Vol. 101 Issue 1 Pg. 132-6 (Jul 1982) ISSN: 0022-3476 [Print] United States
PMID	6177846 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Benzhydryl Compounds Drug Combinations Histamine H1 Antagonists Multi-Ingredient Cold, Flu, and Allergy Medications Nasal Decongestants chlorpheniramine, phenylephrine, phenylpropanolamine, phenyltoloxamine drug combination Phenylephrine Phenylpropanolamine Chlorpheniramine Amoxicillin
Topics	Acoustic Impedance Tests Adolescent Amoxicillin (therapeutic use) Benzhydryl Compounds (therapeutic use) Child Child, Preschool Chlorpheniramine (therapeutic use) Clinical Trials as Topic Drug Combinations (therapeutic use) Drug Therapy, Combination Histamine H1 Antagonists (therapeutic use) Humans Infant Multi-Ingredient Cold, Flu, and Allergy Medications Nasal Decongestants (therapeutic use) Otitis Media (drug therapy) Otitis Media with Effusion (drug therapy) Phenylephrine (therapeutic use) Phenylpropanolamine (therapeutic use) Random Allocation

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