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Heterogeneity of tumorigenicity phenotype in murine tumors. Characterization of tumor clones isolated from primary 3-methylcholanthrene-induced fibrosarcomas.

Abstract
In this study we have characterized three series of clonal populations isolated from primary murine fibrosarcomas induced with three different doses of the chemical carcinogen, 3-methylcholanthrene (3-MCA). Clones were evaluated fro their in vivo growth rates after transplantation into normal syngeneic animals, and for immunological cross-protection toward clones derived from the same tumor. A pattern of reactivity emerged from these studies which supports, at the single-cell level, existing theories regarding the correlation between the inducing dose of chemical carcinogen and the antigenicity of the resulting tumors. Clones from tumors induced with 10 mg of 3-MCA were found to be less tumorigenic than clones from tumors induced with 5 mg of 3-MCA. The 5-mg clones were in turn less tumorigenic than the 1-mg clones, all of which grew rapidly in normal animals. Related clones from each tumor were found for the most part to be immunologically noncross-reactive with other clones from the same tumor, suggesting that subpopulations of tumor cells expressing different tumor-specific transplantation antigens (TSTAs) may reside within single primary tumors. We have used these observations to formulate an hypothesis for the origin of antigenic heterogeneity in 3-MCA-induced tumors and as the basis for a discussion of the relationship between cell transformation and the appearance at the cell surface of tumor-specific transplantation antigens.
AuthorsM Schmitt, R A Daynes
JournalTransplantation (Transplantation) Vol. 33 Issue 4 Pg. 387-92 (Apr 1982) ISSN: 0041-1337 [Print] United States
PMID6176054 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antigens, Heterophile
  • Antigens, Neoplasm
  • Epitopes
  • Methylcholanthrene
Topics
  • Animals
  • Antigens, Heterophile (immunology)
  • Antigens, Neoplasm (immunology)
  • Cell Separation
  • Cell Transformation, Neoplastic (drug effects)
  • Clone Cells (classification, immunology)
  • Dose-Response Relationship, Immunologic
  • Epitopes
  • Female
  • Fibrosarcoma (chemically induced, immunology)
  • Immunity, Cellular
  • Methylcholanthrene
  • Mice
  • Mice, Inbred C3H
  • Phenotype

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