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Effect of alinidine on experimental cardiac arrhythmias.

Abstract
Alinidine (2.9 +/- 0.7 mg/kg) prevented an adrenaline-induced ventricular arrhythmia in dogs respired with halothane. In ouabain-induced ventricular tachycardia, a cumulative dose of alinidine (15.5 mg/kg) reduced the number of ventricular beats by 91.6 +/- 1.9%. The drug was much less effective in abolishing the ventricular tachycardia 24 h after ligation of a coronary artery, with only a 36 +/- 15% reduction in ventricular ectopic beats after 15.5 mg/kg. The administration of alinidine (0.5-1.0 mg/kg) to anaesthetized dogs with no cardiac arrhythmia reduced sinus node rate with little effect on the response of the node to vagal stimulation.
AuthorsD W Harron, J D Allen, R Wilson, R G Shanks
JournalJournal of cardiovascular pharmacology (J Cardiovasc Pharmacol) 1982 Mar-Apr Vol. 4 Issue 2 Pg. 221-5 ISSN: 0160-2446 [Print] United States
PMID6175804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Arrhythmia Agents
  • Ouabain
  • alinidine
  • Clonidine
  • Halothane
  • Epinephrine
Topics
  • Animals
  • Anti-Arrhythmia Agents
  • Arrhythmias, Cardiac (chemically induced, physiopathology)
  • Blood Pressure (drug effects)
  • Clonidine (analogs & derivatives, pharmacology)
  • Coronary Vessels (physiology)
  • Dogs
  • Epinephrine
  • Halothane
  • Heart Rate (drug effects)
  • Ouabain (pharmacology)
  • Sinoatrial Node (physiology)

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