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Effects of hexestrol, medroxyprogesterone acetate and chlormadinone acetate on 7, 12-dimethylbenz [a] anthracene-induced rat mammary cancer in relation to estrogen receptor.

Abstract
The effects of hexestrol (HXS), medroxyprogesterone acetate (MAP) and chlormadinone acetate (CMA) on 7, 12-dimethylbenz [a] anthracene-induced mammary cancer in rats were evaluated. As a result of successive intramuscular injections of HXS at dosages of 2 or 10 mg/kg or MAP at dosages of 24 or 120 mg/Kg, tumors were markedly reduced in size in all groups on day 7 approximately 14. These effects were the same regardless of the presence or absence of cytoplasmic estrogen receptors (ER) in tumors as determined by the dextran-coated charcoal method. Although such an effect was also seen with CMA, it was much less marked than the effects seen with HXS and MAP. The body weights of HXS-administered groups decreased considerably, whereas those of MAP-administered groups increased. These results may suggest that there is another endocrinological tumor-suppressing mechanism besides the mechanism involving the estrogen-ER system in large-dose administration of HXS and MAP.
AuthorsT Tominaga, M Kitamura, T Saito, I Itoh
JournalGan (Gan) Vol. 72 Issue 4 Pg. 604-9 (Aug 1981) ISSN: 0016-450X [Print] Japan
PMID6171473 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Receptors, Estrogen
  • Chlormadinone Acetate
  • Hexestrol
  • 9,10-Dimethyl-1,2-benzanthracene
  • Medroxyprogesterone Acetate
  • Medroxyprogesterone
Topics
  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Body Weight (drug effects)
  • Chlormadinone Acetate (therapeutic use)
  • Delayed-Action Preparations
  • Female
  • Hexestrol (therapeutic use)
  • Mammary Neoplasms, Experimental (chemically induced, drug therapy, metabolism)
  • Medroxyprogesterone (analogs & derivatives, therapeutic use)
  • Medroxyprogesterone Acetate
  • Rats
  • Rats, Inbred Strains
  • Receptors, Estrogen (metabolism)

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