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[Interferon-inducing and protective action of polyguacyl in an experimental influenza infection].

Abstract
A comparative study of the interferon-inducing and anti-influenza activity of polyguacyl, an interferon inducer, given to human volunteers intranasally and as an aerosol, was carried out. The induction of endogenous interferon in the blood to 100-127 units/ml was observed only after intranasal administration of 5 mg polyguacyl. By both routes of administration the inducer did not diminish the implantation of the virus and development of postvaccination reactions in volunteers to intranasal administration of live influenza A (H1N1) vaccine.
AuthorsN P Obrosova-Serova, A N Fomina, A N Slepushkin, I A Grushinskaia, V I Balashov
JournalVoprosy virusologii (Vopr Virusol) 1981 Jul-Aug Issue 4 Pg. 423-8 ISSN: 0507-4088 [Print] Russia (Federation)
Vernacular TitleIzuchenie interferonindutsiruiushchego i zashchitnogo deĭstviia poliguatsila pri éksperimental'noĭ grippoznoĭ infektsii.
PMID6171099 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Aerosols
  • Influenza Vaccines
  • Interferon Inducers
  • Placebos
  • Polyribonucleotides
  • Poly G
  • poly G-poly C
  • Poly C
  • Interferons
Topics
  • Administration, Intranasal
  • Adult
  • Aerosols
  • Drug Evaluation
  • Humans
  • Influenza Vaccines (administration & dosage)
  • Influenza, Human (drug therapy, immunology)
  • Interferon Inducers (administration & dosage, therapeutic use)
  • Interferons (blood)
  • Middle Aged
  • Placebos
  • Poly C (administration & dosage, therapeutic use)
  • Poly G (administration & dosage, therapeutic use)
  • Polyribonucleotides (therapeutic use)
  • Time Factors

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