Biochemical interaction of six OP delayed neurotoxicants with several neurotargets.

Abstract	Five organophosphorous insecticides: Leptophos, EPN, Cyanofenphos, trichloronate and salithion proved to cause irreversible ataxia not only to chicken but also to mice and sheep. TOCP was included as a reference. Cyanofenphos blocked the catecholamine B-receptor binding activity with 3H-norepinephrine at a level similar to that of the specific inhibitor propranolol in the mouse heart preparation. In the lamb heart preparation, the B-receptor was more sensitive to Leptophos, salithion and TOCP than to propranolol. The six compounds and their oxons were screened for their in-vitro inhibition to monamine oxidase (MAO), acetyl cholinesterase (AChE) and neurotoxic esterase (NTE) in the brain of either mouse, lamb or chicken. It is believed that their AChE inhibition stands for their acute toxicity, while NTE inhibition is responsible for their paralytic ataxia.
Authors	A H El-Sebae, S A Soliman, N S Ahmed, A Curley
Journal	Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes (J Environ Sci Health B) Vol. 16 Issue 4 Pg. 465-74 ( 1981) ISSN: 0360-1234 [Print] England
PMID	6169754 (Publication Type: Journal Article)
Chemical References	Cholinesterase Inhibitors Insecticides Neurotoxins Organophosphates Organophosphorus Compounds Organothiophosphates Organothiophosphorus Compounds cyanophenphos EPN oxon Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester trichloronate salioxon salithion cyanofenphos oxon trichloronate oxon leptophos oxon Leptophos Carboxylic Ester Hydrolases neurotoxic esterase
Topics	Animals Ataxia (chemically induced) Brain (drug effects) Carboxylic Ester Hydrolases (antagonists & inhibitors) Chickens Cholinesterase Inhibitors Female Heart (drug effects) Insecticides (toxicity) Leptophos (toxicity) Male Mice Nerve Degeneration (drug effects) Neurotoxins Organophosphates (toxicity) Organophosphorus Compounds (toxicity) Organothiophosphates (toxicity) Organothiophosphorus Compounds (toxicity) Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester (analogs & derivatives, toxicity) Sheep

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