Tumor markers of pancreatic carcinoma.

Abstract

There is no well-defined specific tumor marker for carcinoma of the pancreas. Carcinoembryonic antigen (CEA) and alphafetal protein (AFP) are produced by some pancreatic cancer cells. A pancreatic oncofetal antigen (POA) cross-reacts with other malignant neoplasms and is not produced by all pancreatic carcinomas. An ammonium sulfate fraction (0-25%) from an aqueous extract of pancreatic carcinoma tissues contains an antigen cross-reacting with extracts of other pancreatic carcinomas and various carcinomas representing all three germinal layers. A heterologous antiserum to this antigen cross-reacts with sera from patients with pancreatic carcinomas in a dilution of 1:16,000. At lower dilutions this antiserum reacts with sera from patients with other carcinomas and with sera from some apparently healthy individuals.

• Authors: J V Klavins
• Journal: Cancer (Cancer) Vol. 47 Issue 6 Suppl Pg. 1597-601 (Mar 15 1981) ISSN: 0008-543X [Print] United States
• PMID: 6168354 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Carcinoembryonic Antigen
• Epitopes
• Immune Sera
• alpha-Fetoproteins
• oncofetal antigens

Topics

• Animals
• Antigens, Neoplasm (analysis)
• Carcinoembryonic Antigen (analysis)
• Cross Reactions
• Epitopes
• Goats (immunology)
• Humans
• Immune Sera
• Immunoenzyme Techniques
• Pancreatic Neoplasms (analysis, immunology)
• Rabbits (immunology)
• alpha-Fetoproteins (analysis)