2,4-diaminoanisole-induced thyroid pigmentation in rats inhibited by m-phenylenediamine.

Abstract

The effect of the carcinogenic hair dye component 2,4-diaminoanisole (2,4-DAA) on thyroid and pituitary morphology was studied. Heavy pigmentation of the hypertrophied thyroid epithelium was present when the animals were fed with 2,4-DAA for 6 weeks. Another hair dye component m-phenylenediamine (m-PDA), which lacks the methoxy group, and which is not carcinogenic, prevented the dark pigmentation of the thyroid epithelium caused by 2,4-DAA, but had only a slight effect on the hypertrophy of the gland. In the pituitary gland of 2,4-DAA-fed animals only a few aldehyde fuchsin positive thyrotrope cells were present. When 2,4-DAA and m-PDA were fed simultaneously, the number of hypertrophied chromophobic cells was greatly increased and the aldehyde fuchsin-positive cells were practically absent.

• Authors: R P Evarts, C A Brown
• Journal: Toxicology letters (Toxicol Lett) 1981 Jun-Jul Vol. 8 Issue 4-5 Pg. 257-64 ISSN: 0378-4274 [Print] Netherlands
• PMID: 6168031 (Publication Type: Journal Article)

Chemical References

• Anisoles
• Phenylenediamines
• 4-methoxy-3-phenylenediamine

Topics

• Animals
• Anisoles (antagonists & inhibitors, pharmacology)
• Female
• Phenylenediamines (antagonists & inhibitors, pharmacology)
• Pigmentation Disorders (pathology)
• Pituitary Gland (cytology)
• Rats
• Staining and Labeling
• Thyroid Gland (cytology)