[Antiviral treatment of subacute sclerosing panencephalitis].

Abstract

The natural outcome of SSPE which is as a rule unfavourable independently of the treatment given, and this indicates the necessity of studies on new methods of treatment. After failures of steroids, immunosuppressants and transfer factor the treatment with virostatic drugs seems to be most safe and justified. The paper contains preliminary results of clinical observations of 34 patients with SSPE treated with amantadine, ITF (a derivative of isothiazole) and isoprinosine. In some cases it was tried to correlate the results of treatment with those of immunological and electrophysiological investigations. The presented data are insufficient for a reliable conclusion to be drawn concerning the effect of various drugs on the course of SSPE, nevertheless, it seems that the best results with slowing down of the progression of the disease were observed in the group treated with isoprinosine.

• Authors: W Sobczyk, J Kulczycki
• Journal: Neurologia i neurochirurgia polska (Neurol Neurochir Pol) 1981 Mar-Apr Vol. 15 Issue 2 Pg. 143-8 ISSN: 0028-3843 [Print] Poland
• Vernacular Title: Uwagi na temat przeciwwirusowego leczenia podostrego stwardniajacego zapalenia mózgu.
• PMID: 6167886 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Thiazoles
• Amantadine
• Inosine Pranobex

Topics

• Adolescent
• Adult
• Amantadine (therapeutic use)
• Antiviral Agents (therapeutic use)
• Child
• Child, Preschool
• Clinical Trials as Topic
• Female
• Humans
• Inosine Pranobex (therapeutic use)
• Male
• SSPE Virus (drug effects)
• Subacute Sclerosing Panencephalitis (drug therapy)
• Thiazoles (therapeutic use)