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Hemoglobin Brisbane: beta68 Leu replaced by His. A new high oxygen affinity variant.

Abstract
Hemoglobin Brisbane is a new hemoglobin variant which produces a mile erythrocytosis. It is not detectable by electrophoresis at pH 8.6 or by isoelectric focusing but it is mildly unstable and gives a positive result with standard stability tests. The new hemoglobin has increased oxygen affinity and reduced co-operativity with a normal Bohr effect and 2,3-DPG binding. Structural analysis shows that a histidine residue has replaced the leucine normally found at position beta 68 (E12).
AuthorsS O Brennan, R M Wells, H Smith, R W Carrell
JournalHemoglobin (Hemoglobin) Vol. 5 Issue 4 Pg. 325-35 ( 1981) ISSN: 0363-0269 [Print] England
PMID6166590 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diphosphoglyceric Acids
  • Hemoglobins, Abnormal
  • Peptides
  • hemoglobin Brisbane
  • Hemoglobin A
  • Fetal Hemoglobin
  • Trypsin
Topics
  • Adult
  • Amino Acid Sequence
  • Australia
  • Diphosphoglyceric Acids (blood)
  • Female
  • Fetal Hemoglobin
  • Genetic Variation
  • Hemoglobin A
  • Hemoglobins, Abnormal
  • Humans
  • Male
  • Middle Aged
  • Oxygen Consumption
  • Peptides
  • Trypsin (pharmacology)

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