The treatment of decubitus ulcers with dextranomer.

Twenty-five patients with 35 bedsores were treated with dextranomer (Debrisan; Adcock Ingram) applied topically to the ulcers. Fourteen patients had ulcers which penetrated fascia, muscle and bone, 4 had superficial ulcers and 2 had discharging sinuses. Most of the severe ulcers healed rapidly and were cleansed and ready for surgery at an average of 14.6 days. The superficial ulcers were completely healed within 3 weeks. Treatment of the sinuses with dextranomer using a catheter/syringe technique resulted in wound closure within 28 days. In a representative sample of 12 patients in whom the surface area of the ulcers was measured by means of a planimeter, there was a median reduction in surface area of 44.8% by the 2nd week (P=0,0002) and 79% (P=0,001) at the end of the 4th week. The median percentage reduction in depth was 66.7% (P=0,008) at the end of the 4th week.
AuthorsR D Shrosbree, P Engel
JournalSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 59 Issue 25 Pg. 902-4 (Jun 13 1981) ISSN: 0256-9574 [Print] SOUTH AFRICA
PMID6165087 (Publication Type: Journal Article)
Chemical References
  • dextranomer
  • Dextrans
  • Administration, Topical
  • Adolescent
  • Adult
  • Dextrans (administration & dosage, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pressure Ulcer (drug therapy)
  • Time Factors
  • Wound Healing (drug effects)

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