Placenta-associated plasma protein-A (PAPP-A, SP4) in trophoblastic tumours.

Abstract

The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas. PAPP-A was found in the syncytiotrophoblast of all hydatidiform moles, in 5 of the 6 invasive moles and in 6 of the 7 choriocarcinomata. No clinical difference was observed between PAPP-A positive and negative cases of invasive disease.

• Authors: T Wahlström, B Teisner, J N Lee, J G Grudzinskas, M Seppälä, J Folkersen
• Journal: Acta pathologica et microbiologica Scandinavica. Section A, Pathology (Acta Pathol Microbiol Scand A) Vol. 89 Issue 1 Pg. 65-6 (Jan 1981) ISSN: 0365-4184 [Print] Denmark
• PMID: 6164245 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pregnancy Proteins
• Pregnancy-Associated Plasma Protein-A

Topics

• Choriocarcinoma (analysis)
• Female
• Humans
• Immunoenzyme Techniques
• Pregnancy
• Pregnancy Proteins (analysis)
• Pregnancy-Associated Plasma Protein-A (analysis)
• Trophoblastic Neoplasms (analysis)
• Uterine Neoplasms (analysis)