6-sulphanilamidoindazole arthritis of rats: relation between acute-phase proteins, degree of arthritis and treatment with soybean trypsin inhibitor.

Abstract

During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups was proved to be significantly decreased. Intravenous administration of 5 mg/kg soybean trypsin inhibitor, twice daily for 4 days, was without any inhibitory effect on paw swelling in 6-SAI arthritis but it caused increased serum levels of alpha 2 macroglobulin and Darcy's glycoprotein. Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. via protease inhibition. Evidence is presented which shows that spontaneous remission of 6-SAI arthritis could be due to local processes.

• Authors: R Hirschelmann, R Schade, H Bekemeier
• Journal: Agents and actions (Agents Actions) Vol. 10 Issue 5 Pg. 431-4 (Nov 1980) ISSN: 0065-4299 [Print] Switzerland
• PMID: 6163339 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Glycoproteins
• Indazoles
• Sulfanilamides
• Trypsin Inhibitors
• alpha-Macroglobulins
• 6-sulfanilamidoindazole

Topics

• Animals
• Arthritis (blood, chemically induced, drug therapy)
• Female
• Glycoproteins (blood)
• Indazoles
• Male
• Rats
• Remission, Spontaneous
• Sulfanilamides
• Time Factors
• Trypsin Inhibitors (pharmacology)
• alpha-Macroglobulins (metabolism)