HBs Ag and hepatocellular carcinoma associated with cirrhosis.--A retrospective study based on autopsy.

Abstract

Histologic specimens of liver tissue from 33 consecutive cases of hepatocellular carcinoma (HCC) associated with cirrhosis, were stained with hematoxylin-eosin and with orcein for the presence of HBs Ag in the cytoplasm of cells. Such a study showed orcein-positive liver cells in 7 out of 33 (21.2%) cases of HCC associated with cirrhosis. The clinical course and laboratory examinations of the 33 patients were also reviewed and revealed a significant difference between the length of survival of orcein-positive patients and orcein-negative ones. Therefore, these results seem to support the hypothesis that HBs Ag may play a role not only in the development of HCC associated with cirrhosis, but also in a more rapid and severe course of neoplasia.

• Authors: F M Vecchio, M A Dina
• Journal: Hepato-gastroenterology (Hepatogastroenterology) Vol. 27 Issue 5 Pg. 365-8 (Oct 1980) ISSN: 0172-6390 [Print] Greece
• PMID: 6162768 (Publication Type: Journal Article)

Chemical References

• Coloring Agents
• Hepatitis B Surface Antigens
• Oxazines
• PAcein
• Eosine Yellowish-(YS)
• Hematoxylin

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (etiology, pathology)
• Coloring Agents
• Cytoplasm (immunology)
• Eosine Yellowish-(YS)
• Female
• Hematoxylin
• Hepatitis B Surface Antigens (adverse effects, isolation & purification)
• Humans
• Liver (pathology)
• Liver Cirrhosis (complications)
• Liver Neoplasms (etiology, pathology)
• Male
• Middle Aged
• Oxazines
• Staining and Labeling