[Organ-specific human prostate beta-globulin during tumor growth].

Abstract

An organ specific protein antigen having an electrophoretic mobility of beta-globulin was demonstrated in human prostate. Its physicochemical properties (relative electrophoretic mobility, diffusion coefficient, molecular weight and relation to different precipitating agents) were determined. The indirect immunofluorescence technique revealed that this antigen is synthesized by the glandular epithelium of the main glands. A statistically significant decrease was found in the concentration of prostatic beta-globulin in tumors of the prostate. The synthesis of this protein was shown to start only in the period of puberty.

• Authors: A A Nikolaev, A V Afanas'eva, Iu Kh Khaĭrullin
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 90 Issue 11 Pg. 583-6 (Nov 1980) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Organospetsificheskiĭ beta-globulin predstatel'noĭ zheleza cheloveka v usloviiakh opukholevogo rosta.
• PMID: 6160885 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antigens
• Antigens, Neoplasm
• Beta-Globulins

Topics

• Antigens (analysis)
• Antigens, Neoplasm (analysis)
• Beta-Globulins (analysis)
• Fluorescent Antibody Technique
• Humans
• Immunodiffusion
• Immunoelectrophoresis
• Male
• Organ Specificity
• Prostate (analysis, embryology, immunology)
• Prostatic Neoplasms (analysis, immunology)