[Early therapy with immunoglobulins after extensive abdominal operations. A random study (author's transl)].

Abstract

A random study with 100 patients was conducted to show whether the immunoglogulin Gamma Venin, when given after rectum extirpation, has an effect on wound healing and other infections. The patients in the test group received 10 g of Gamma Venin within the first 48 h after surgery. The number of days with purulent wound secretion were reduced to 0.71 (test group) as opposed to 7.61 (control) with statistical significance. Primary wound healing was 37% in the test group and 9% in the control group (P < 0.01). Other infections occurred in a similar range. The time of hospitalization was 3.44 days less than in the test group (P < 0.01).

• Authors: M Probst, W Fabian
• Journal: Langenbecks Archiv fur Chirurgie (Langenbecks Arch Chir) Vol. 351 Issue 2 Pg. 85-9 ( 1980) ISSN: 0023-8236 [Print] Germany
• Vernacular Title: Die Frühtherapie mit Immunglobulinen nach grossen abdominalchirurgischen Eingriffen. Eine prospektive randomisierte Studie.
• PMID: 6160364 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Immunoglobulin Fab Fragments
• gamma-Globulins

Topics

• Abdomen (surgery)
• Clinical Trials as Topic
• Humans
• Immunoglobulin Fab Fragments (therapeutic use)
• Length of Stay
• Random Allocation
• Rectum (surgery)
• Wound Healing (drug effects)
• Wound Infection (drug therapy)
• gamma-Globulins (therapeutic use)