Abstract |
The ability of dipropylacetic acid (DPA) and dipropylacetamide (DPM) to modify EEG and seizure activity was assessed in 4 female and 3 male Papio papio. Doses of 30-60 mg/kg of DPA given at intervals over an 8 h period produced blood levels of 19-44 micrograms/ml which were not protective against intermittent light stimulation (ILS). Administration of 150-200 mg/kg doses at intervals over a 36 h period produced blood levels greater than 150 micrograms/ml and were highly protective against ILS. Similar results were obtained following adminstration of DPM; however, DPM appeared to offer greater protection against ILS. A moderate amount of seizure control was obtained at blood levels of 60-91 micrograms/ml (DPA) and complete blockade occurred at levels greater than 100 micrograms/ml DPA. Background EEG changes were similar following either DPA or DPM and consisted of a striking increase in total spectral power with relative power changes in 10-20 c/sec range, the magnitude of which was related to blood levels of DPA. Both agents produced a quieting effect on behavior without severe depression.
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Authors | C L Ehlers, L W Mulbry, E K Killam |
Journal | Electroencephalography and clinical neurophysiology
(Electroencephalogr Clin Neurophysiol)
Vol. 49
Issue 3-4
Pg. 391-400
(Aug 1980)
ISSN: 0013-4694 [Print] Ireland |
PMID | 6158417
(Publication Type: Journal Article)
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Chemical References |
- Valproic Acid
- dipropylacetamide
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Topics |
- Animals
- Cerebral Cortex
(drug effects)
- Dose-Response Relationship, Drug
- Electroencephalography
(methods)
- Female
- Male
- Papio
- Seizures
(blood, drug therapy)
- Valproic Acid
(analogs & derivatives, blood, pharmacology)
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