[Immunological determination of epidermal G2-chalone as a squamous cell marker in lung tumors in rats].

Abstract

Epidermal G2 chalone was determined in induced rat lung tumors by the double immunodiffusion test or by immunoautoradiography. Epidermal chalone normally contained by keratinized tissues alone was detected in squamous cell lung carcinomas or adenomas with areas of squamous cell differentiation rather than in so-called pure adenocarcinomas. The antigen concentration correlated with the expansion of the areas of squamous cell differentiation. Thus the detection of epidermal G2 chalone can serve as marker of squamous cell metaplasia in the rat lung tissue.

• Authors: V B Okulov, M A Zabezhinskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 90 Issue 8 Pg. 248-9 (Aug 1980) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Immunologicheskoe opredelenie épidermal'nogo G2-keĭlona kak markera ploskokletochnykh struktur v opukholiakh legkikh krys.
• PMID: 6157440 (Publication Type: English Abstract, Journal Article)

Chemical References

• Epitopes
• Growth Inhibitors

Topics

• Animals
• Autoradiography
• Carcinoma, Squamous Cell (immunology)
• Epitopes (analysis)
• Growth Inhibitors (analysis)
• Immunodiffusion (methods)
• Lung Neoplasms (immunology)
• Male
• Neoplasms, Experimental (immunology)
• Rats
• Skin (immunology)