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Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease.

AbstractThe ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients with acute hepatitis. We feel that the use of the ratio as a test of early liver cell dysfunction requires further evaluation, in particular in the early recognition of metastatic liver disease.
AuthorsO E Eade, A Maddison, P J Leonard, R Wright
JournalDigestion (Digestion) Vol. 16 Issue 1-2 Pg. 169-74 ( 1977) ISSN: 0012-2823 [Print] SWITZERLAND
PMID615730 (Publication Type: Journal Article)
Chemical References
  • 17-Hydroxycorticosteroids
  • Hydrocortisone
Topics
  • 17-Hydroxycorticosteroids (urine)
  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Cholestasis (urine)
  • Female
  • Hepatitis (urine)
  • Hepatitis, Alcoholic (urine)
  • Humans
  • Hydrocortisone (analogs & derivatives, urine)
  • Liver Cirrhosis, Alcoholic (urine)
  • Liver Diseases (urine)
  • Liver Neoplasms (urine)
  • Male
  • Middle Aged
  • Neoplasm Metastasis

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