Elevated glycosyltransferase activities in infected or traumatized hosts: nonspecific response to inflammation.

Abstract

Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma.

• Authors: P G Canonico, J S Little, M C Powanda, K A Bostian, W R Beisel
• Journal: Infection and immunity (Infect Immun) Vol. 29 Issue 1 Pg. 114-8 (Jul 1980) ISSN: 0019-9567 [Print] United States
• PMID: 6156910 (Publication Type: Journal Article)

Chemical References

• alpha-Macroglobulins
• Transferases
• Fucosyltransferases
• Galactosyltransferases
• Glucosyltransferases
• N-Acetylglucosaminyltransferases
• N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
• Sialyltransferases
• Acetylglucosamine

Topics

• Acetylglucosamine (metabolism)
• Animals
• Burns (enzymology)
• Fucosyltransferases (metabolism)
• Galactosyltransferases (metabolism)
• Glucosyltransferases (metabolism)
• Humans
• Inflammation (enzymology)
• Liver (enzymology)
• Male
• N-Acetylglucosaminyltransferases
• Phlebotomus Fever (enzymology)
• Pneumococcal Infections (enzymology)
• Rats
• Sialyltransferases (metabolism)
• Transferases (metabolism)
• alpha-Macroglobulins (metabolism)