[Dynamics of the cytoplasmic RNA content in the sympathetic neurons in a synaptic block].

Abstract

Cytophotometry of RNA was carried out in the neurons of the superior cervical sympathetic ganglion of the adult rabbits under the effect of various doses of the ganglion blocking agent dimecolin. Marked oscillations in the RNA content were observed in the neuronal cytoplasm after administration of the preparation. Dynamics of revealed shifts significantly differed depending on the dose of the preparation, and it was similar in the mono- and binucleated neurons. On the basis of the analysis of the character of variations revealed it is suggested that the synaptic processes have an important role in the development of quantitative RNA shifts in postsynaptic neurones. The results obtained indicate that the functional activity in some ganglioid neurones increases after administration of various doses of dimecolin during the blockade and after its termination.

• Authors: P L Gorelikov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 89 Issue 2 Pg. 232-4 (Feb 1980) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Dinamika soderzhaniaa tsitoplazmaticheskoĭ RNK simpaticheskikh neĭronov pri sinapticheskoĭ blokade.
• PMID: 6154492 (Publication Type: Journal Article)

Chemical References

• Ganglionic Blockers
• Pipecolic Acids
• dimecolin
• RNA

Topics

• Animals
• Cytoplasm (metabolism)
• Dose-Response Relationship, Drug
• Ganglionic Blockers (pharmacology)
• Nerve Block (methods)
• Neurons (metabolism)
• Pipecolic Acids
• RNA (metabolism)
• Rabbits
• Sympathetic Nervous System (metabolism)
• Synapses (drug effects)