Inhibition of hepatic drug metabolism by (+)-cyanidanol-3 (Catergen) in chronic alcoholic liver disease.

Abstract

There are some controversies regarding the effect of (+)-cyanidanol-3 on hepatic drug metabolism. In the present study the effect of (+)-cyanidanol-3 was investigated on the microsomal and mitochondrial enzyme functions (hydroxylation, glucuronide production, D-glucaric acid excretion and acetylation) in alcoholic liver disease. Eight patients with biopsy-proven chronic alcoholic hepatitis were investigated before and after a 10-day, as well as after a further 30-day, treatment with (+)-cyanidanol-3 (Catergen), 3000 mg/day orally. Besides biochemical liver function tests (serum bilirubin levels, GOT, GGT), antipyrine metabolic clearance rate, mentholglucuronide production, urinary D-glucaric acid excretion and sulphadimidine kinetics were determined. Biochemical liver function tests improved markedly after the first period of treatment, at the same time antipyrine metabolic clearance rate decreased. Menthol-glucuronide production and D-glucaric acid excretion decreased significantly only after the second two course of Catergen administration. Sulphadimidine kinetics was not remarkably changed. Our findings suggest that (+)-cyanidanol-3 inhibits the hepatic microsomal drug metabolizing enzyme function in chronic alcoholic hepatitis.

• Authors: A Pár, T Horváth, T Beró, I Kádas, F Pakodi, T Jávor
• Journal: Acta physiologica Hungarica (Acta Physiol Hung) Vol. 64 Issue 3-4 Pg. 449-54 ( 1984) ISSN: 0231-424X [Print] Hungary
• PMID: 6152369 (Publication Type: Journal Article)

Chemical References

• Benzopyrans
• Glucuronates
• Menthol
• Sulfamethazine
• menthol glucuronide
• Catechin
• gamma-Glutamyltransferase
• Aspartate Aminotransferases
• Glucaric Acid
• Antipyrine

Topics

• Adult
• Antipyrine (metabolism)
• Aspartate Aminotransferases (metabolism)
• Benzopyrans (therapeutic use)
• Catechin (therapeutic use)
• Glucaric Acid (metabolism)
• Glucuronates (metabolism)
• Hepatitis, Alcoholic (drug therapy, enzymology)
• Humans
• Inactivation, Metabolic (drug effects)
• Liver (drug effects, enzymology)
• Liver Function Tests
• Male
• Menthol (analogs & derivatives, metabolism)
• Metabolic Clearance Rate (drug effects)
• Sulfamethazine (metabolism)
• gamma-Glutamyltransferase (metabolism)