Norzimelidine, a metabolite of a highly selective 5-hydroxytryptamine uptake inhibitor, can inhibit the uptake of noradrenaline in-vivo.

Abstract

Zimelidine and norzimelidine were tested for their ability to counteract reserpine (2.5 mg kg-1)- or apomorphine (1-16 mg kg-1)-induced hypothermia and to potentiate TRH (40 mg kg-1)-induced hyperthermia in mice. Norzimelidine produced positive results in all three tests, behaving like a weak NA uptake inhibitor. Zimelidine was practically inactive. We conclude that the weak inhibitory effect of norzimelidine on the uptake of NA (in-vitro experiments) may be of importance for its pharmacological action and for the clinical action of zimelidine.

• Authors: L Pawłowski, H Mazela
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 36 Issue 12 Pg. 855-8 (Dec 1984) ISSN: 0022-3573 [Print] England
• PMID: 6151986 (Publication Type: Journal Article)

Chemical References

• Antidepressive Agents
• Propylamines
• Citalopram
• Zimeldine
• norzimelidine
• Thyrotropin-Releasing Hormone
• Reserpine
• Apomorphine
• Norepinephrine

Topics

• Animals
• Antidepressive Agents (pharmacology)
• Apomorphine (pharmacology)
• Body Temperature (drug effects)
• Citalopram
• Male
• Mice
• Norepinephrine (metabolism)
• Propylamines (pharmacology)
• Reserpine (pharmacology)
• Thyrotropin-Releasing Hormone (pharmacology)
• Zimeldine (analogs & derivatives, pharmacology)