Tyr-MIF-1 acts as an opiate antagonist in the tail-flick test.

Abstract

The naturally occurring brain peptide Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) was tested for its ability to block and reverse the actions of morphine in the tail-flick test. Injected peripherally either 10 minutes before or after morphine, Tyr-MIF-1, like MIF-1, was found to significantly reduce the antinociceptive actions of morphine on thermal pain. The results indicate that Tyr-MIF-1 may act, in part, as an endogenous opiate antagonist.

• Authors: A J Kastin, E Stephens, R H Ehrensing, A J Fischman
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 21 Issue 6 Pg. 937-41 (Dec 1984) ISSN: 0091-3057 [Print] United States
• PMID: 6151669 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Narcotic Antagonists
• Naloxone
• Morphine
• tyrosyl-prolyl-leucyl-glycinamide
• MSH Release-Inhibiting Hormone

Topics

• Animals
• Hot Temperature (adverse effects)
• MSH Release-Inhibiting Hormone (analogs & derivatives, pharmacology)
• Male
• Mice
• Mice, Inbred ICR
• Morphine (antagonists & inhibitors)
• Naloxone (pharmacology)
• Narcotic Antagonists
• Pain (drug therapy)