Early liver alterations induced by the sex-dependent hepatocarcinogen beta-blocker ZAMI 1305.

Abstract

Liver alterations occurring after 1, 6 or 10 days of treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butyl-amino-propan-2-ol (ZAMI 1305) were studied in male and female Wistar rats. In agreement with its sex-dependent oncogenicity, ZAMI 1305 administration causes DNA damage in the liver of the female but not of the male rat, with the only exception of 2 out of 4 males treated for 6 days. In female rat, the amount of DNA damage increases from 1 to 6 days of treatment, being unchanged at 10 days; a small portion of DNA is however damaged. ZAMI 1305 administration to female rat induces also: (i) an increase of the relative liver weight, of the DNA and RNA synthesizing activity; (ii) a decrease of the number of hepatocytes in mitosis; (iii) a minimal oval cell hyperplasia. When the same parameters were studied in ZAMI 1305-treated male rats, they were unaffected or changed to a less extent in respect to female rats.

• Authors: M Presta, C Mazzocchi, S Ziliani, T Zavanella, G Ragnotti
• Journal: Chemico-biological interactions (Chem Biol Interact) Vol. 52 Issue 2 Pg. 203-12 (Dec 1984) ISSN: 0009-2797 [Print] Ireland
• PMID: 6150768 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Carcinogens
• Propanolamines
• ZAMI 1305
• Aspartate Aminotransferases

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Aspartate Aminotransferases (blood)
• Carcinogens
• Cell Nucleus (drug effects, metabolism)
• DNA Replication (drug effects)
• Female
• Liver (drug effects, metabolism, pathology)
• Male
• Propanolamines (pharmacology)
• Rats
• Rats, Inbred Strains
• Sex Factors
• Transcription, Genetic (drug effects)