Effect of concurrent administration of
sucralfate on the bioavailability of
indenolol in rats has been investigated. Albino rats were administered with lg/kg
body weight of
sucralfate just before the
oral administration of
indenolol solution (10 mg/kg), blood samples were collected at 0,15,30,45,60,120,240 and 360 minutes after the administration of drugs.
Indenolol concentration was determined spectrofluorometrically, 2,4, and 6-hour Area Under the Curve (AUC) was calculated. The peak
indenolol blood concentration was observed at 45th minute of
drug administration. The level in rats treated with
indenolol alone (2.46 +/- 0.07 microgram/ml) and
indenolol along with
sucralfate (1.21 +/- 0.06 microgram/ml) suggested more than a 50% decrease. There were 36.4%, 27.2% and 20.4% decrease in 2-hour AUC, 4-hour AUC and 6-hour AUC respectively. The data suggest that
sucralfate significantly decreased the absorption of
indenolol, especially in the early phase after administration and clinically significant interaction may occur due to concurrent administration of
indenolol with
sucralfate.