A call for caution in the use of aminoglutethimide: negative interactions with dexamethasone and beta blocker treatment.

Abstract	Two case reports are described, both breast carcinoma patients with metastatic disease. One of the patients had a dexamethasone dependent brain metastatic condition. The second patient suffered from high blood pressure, which was controlled with beta-blocker drugs. Both patients developed severe complications when treated with aminoglutethimide as a cancer hormonal therapy. The case reports are described and possible drug interaction mechanisms are discussed.
Authors	J Halpern, R Catane, H Baerwald
Journal	Journal of medicine (J Med) Vol. 15 Issue 1 Pg. 59-63 ( 1984) ISSN: 0025-7850 [Print] United States
PMID	6149250 (Publication Type: Case Reports, Journal Article)
Chemical References	Adrenergic beta-Antagonists Aminoglutethimide Dexamethasone Propranolol
Topics	Adrenergic beta-Antagonists (adverse effects) Aged Aminoglutethimide (adverse effects, therapeutic use) Brain Neoplasms (secondary) Breast Neoplasms (drug therapy) Dexamethasone (adverse effects) Drug Interactions Drug Therapy, Combination Female Humans Hypertension (drug therapy) Middle Aged Propranolol (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!