Long-term experience with nadolol in treatment of hypertension and angina pectoris.

Abstract	Two-hundred ninety-one patients with hypertension and 313 patients with angina pectoris were enrolled and treated with nadolol for up to 2 years. The efficacy of nadolol in hypertension and angina was maintained over the 2-year period. Discontinuation because of an adverse reaction occurred with 8.3% of the hypertensive patients and 8.6% of the angina patients. The observed reactions were typical of those which occur with beta-blocking drugs. Serum creatinine levels fell significantly (p less than 0.05) after 12 months of treatment for both the angina and hypertensive patients. After 24 months of treatment the serum creatinine levels had decreased 20% from baseline (p less than 0.001). Blood urea nitrogen levels fell in the angina patients after 12 months of treatment but not in the hypertensive patients. Nadolol is safe and effective for the long-term treatment of both hypertension and angina. Renal function, as measured by serum creatinine levels, improved with long-term treatment.
Authors	J C Alexander, M H Christie, K A Vernam, R S Fand, W B Shafer
Journal	American heart journal (Am Heart J) Vol. 108 Issue 4 Pt 2 Pg. 1136-40 (Oct 1984) ISSN: 0002-8703 [Print] United States
PMID	6148874 (Publication Type: Clinical Trial, Journal Article)
Chemical References	Adrenergic beta-Antagonists Diuretics Propanolamines Nadolol Creatinine
Topics	Adolescent Adrenergic beta-Antagonists (adverse effects, therapeutic use) Adult Aged Angina Pectoris (drug therapy) Blood Pressure (drug effects) Blood Urea Nitrogen Clinical Trials as Topic Creatinine (blood) Diuretics (therapeutic use) Dizziness (chemically induced) Drug Therapy, Combination Erectile Dysfunction (chemically induced) Fatigue (chemically induced) Female Heart Rate (drug effects) Humans Hypertension (drug therapy) Male Middle Aged Nadolol Propanolamines (adverse effects, therapeutic use) Respiratory Sounds Sleep Stages Time Factors

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