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The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.

Abstract
The elevated atmospheric pressure at which the main features of the high pressure neurological syndrome (HPNS), i.e. tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg). The onset pressure for tremor is lower in fasted rats. 2-Amino-7-phosphonoheptanoic acid raises the onset pressure for all three phases of HPNS in fed rats, but only for tremor and convulsions in fasted rats. The results are interpreted in terms of changes in aspartergic and related excitatory neurotransmission.
AuthorsB Wardley-Smith, B S Meldrum, M J Halsey
JournalNeuroscience letters (Neurosci Lett) Vol. 48 Issue 2 Pg. 155-60 (Jul 27 1984) ISSN: 0304-3940 [Print] Ireland
PMID6148724 (Publication Type: Journal Article)
Chemical References
  • Amino Acids
  • Glutamates
  • Aspartic Acid
  • Glutamic Acid
  • 2-Amino-5-phosphonovalerate
  • 2-amino-7-phosphonoheptanoic acid
Topics
  • 2-Amino-5-phosphonovalerate (analogs & derivatives)
  • Amino Acids (therapeutic use)
  • Animals
  • Aspartic Acid (physiology)
  • Atmospheric Pressure
  • Brain (physiopathology)
  • Fasting
  • Glutamates (physiology)
  • Glutamic Acid
  • Male
  • Myoclonus (prevention & control)
  • Rats
  • Rats, Inbred Strains
  • Seizures (prevention & control)
  • Synaptic Transmission
  • Syndrome
  • Tremor (prevention & control)

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