Effect of neuroleptic treatment on involuntary movements and motor performances in Huntington's disease.

Abstract

Eighteen patients with Huntington's chorea were examined before and after neuroleptic treatment (haloperidol, pimozide, tiapride) to study the effect of such treatment on hyperkinesia and motor performance. Pimozide and haloperidol improved hyperkinesia; none of the drugs significantly affected motor performance. No correlation was found between the severity of hyperkinesia and motor performance scores, or between hyperkinesia and intelligence score, before and after therapy.

• Authors: F Girotti, F Carella, G Scigliano, M P Grassi, P Soliveri, P Giovannini, E Parati, T Caraceni
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 47 Issue 8 Pg. 848-52 (Aug 1984) ISSN: 0022-3050 [Print] England
• PMID: 6147393 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents
• Pimozide
• Haloperidol
• Tiapamil Hydrochloride

Topics

• Adult
• Antipsychotic Agents (therapeutic use)
• Female
• Haloperidol (therapeutic use)
• Humans
• Huntington Disease (drug therapy)
• Male
• Middle Aged
• Motor Activity (drug effects)
• Motor Skills (drug effects)
• Pimozide (therapeutic use)
• Psychomotor Performance (drug effects)
• Tiapamil Hydrochloride (therapeutic use)