Temazepam's efficacy in patients with sleep onset insomnia.

Abstract

The hypnotic efficacy of temazepam capsules (30 mg) was studied in twelve patients who had objective polysomnographic evidence of sleep onset insomnia. Patients slept in the laboratory, retiring at their usual bedtime after taking placebo or temazepam 30 min earlier, and were monitored for 8 h using standard polysomnographic techniques. Acute (nights 5-7) and chronic (nights 11-13) temazepam improved the sleep of these patients by reducing sleep latency and increasing sleep time compared to the placebo baseline (nights 2-4). No detrimental effects on daytime function the following morning were observed using questionnaires and objective tests of performance. No consistent evidence of disturbed sleep after discontinuation of treatment was obtained over three recovery nights.

• Authors: T Roehrs, J Lamphere, C Paxton, R Wittig, F Zorick, T Roth
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 17 Issue 6 Pg. 691-6 (Jun 1984) ISSN: 0306-5251 [Print] England
• PMID: 6146327 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Temazepam

Topics

• Adult
• Anti-Anxiety Agents (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Electroencephalography
• Electromyography
• Electrooculography
• Female
• Humans
• Male
• Middle Aged
• Random Allocation
• Sleep (physiology)
• Sleep Initiation and Maintenance Disorders (drug therapy)
• Temazepam (adverse effects, therapeutic use)
• Time Factors