Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions.

Abstract

The cardiovascular effects of RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] were examined in normotensive, anaesthetized rats. RDS-127 given i.v. (12.5-125 micrograms kg-1) produced dose-dependent bradycardia. The bradycardic effect was 20.5 times more potent when the drug was administered intracerebroventricularly (i.c.v.) than when given i.v. RDS-127 produced a slight, but significant hypotension. Haloperidol given i.c.v. or i.v. reversed these bradycardic and hypotensive actions, whereas phentolamine was ineffective. Methylatropine partially reduced the bradycardic effect. These results suggest that RDS-127 activates central DA receptors to produce hypotension and bradycardia in rats.

• Authors: S P Arnerić, J P Long
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 36 Issue 5 Pg. 318-21 (May 1984) ISSN: 0022-3573 [Print] England
• PMID: 6145768 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Atropine Derivatives
• Indans
• Indenes
• Receptors, Dopamine
• methylatropine
• 2-N,N-di-n-propylamino-4,7-dimethoxyindan
• Haloperidol
• Phentolamine

Topics

• Animals
• Atropine Derivatives (pharmacology)
• Blood Pressure (drug effects)
• Brain (drug effects)
• Drug Interactions
• Haloperidol (pharmacology)
• Heart Rate (drug effects)
• Hemodynamics (drug effects)
• Indans (administration & dosage, pharmacology)
• Indenes (pharmacology)
• Injections, Intravenous
• Injections, Intraventricular
• Male
• Phentolamine (pharmacology)
• Rats
• Rats, Inbred Strains
• Receptors, Dopamine (drug effects)