Multiple-dose halazepam kinetics.

Abstract

Halazepam is a benzodiazepine used in the management of anxiety disorders or short-term relief of anxiety. Our study was undertaken to evaluate its steady-state kinetics and those of its major active plasma metabolite N- desalkylhalazepam . Eleven healthy men aged 19 to 35 yr were given oral, 40-mg halazepam tablets every 8 hr for 14 days. Plasma samples were analyzed by gas chromatography to determine levels of halazepam and N- desalkylhalazepam . Halazepam kinetics can best be described by a two-compartment open model with first-order absorption kinetics. The elimination phase t1/2s of halazepam and N- desalkylhalazepam were 34.7 and 57.9 hr. Steady-state levels were predictable from kinetic data and were reached by the third day for halazepam and by the eleventh day for N- desalkylhalazepam .

• Authors: M Chung, J M Hilbert, R P Gural, E Radwanski, S Symchowicz, N Zampaglione
• Journal: Clinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 35 Issue 6 Pg. 838-42 (Jun 1984) ISSN: 0009-9236 [Print] United States
• PMID: 6145534 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Benzodiazepines
• halazepam
• Nordazepam

Topics

• Adult
• Anti-Anxiety Agents (blood, metabolism)
• Benzodiazepines
• Benzodiazepinones (blood, metabolism)
• Humans
• Kinetics
• Male
• Nordazepam (blood)