A physiologically active kainic acid-preferring receptor in chicken retina.

Abstract

Neurotoxicity induced by intravitreal injections of kainic acid in the chicken retina was effectively antagonized by piperidine 2,3-dicarboxylic acid and to a lesser extent D-gamma-glutamylglycine. 2-Amino-5-phosphonovaleric acid and glutamic acid diethyl ester were much less effective antagonists. These effects probably result from interactions with a kainic acid-preferring receptor localized on the OFF-centre bipolar cells. Piperidine 2,3-dicarboxylic acid and D-gamma-glutamylglycine also blocked selectively the OFF-responses of ganglion cells while glutamic acid diethyl ester was without effect. 2-Amino-5-phosphonovaleric acid rapidly blocked ON and, much more slowly, OFF-responses. These results are consistent with a role for kainic acid-preferring receptors located on the OFF-centre bipolar cells in chicken retina in physiological transmission between photoreceptors and the OFF-centre bipolar cells.

• Authors: I G Morgan, D R Dvorak
• Journal: Neuroscience letters (Neurosci Lett) Vol. 44 Issue 3 Pg. 299-304 (Feb 24 1984) ISSN: 0304-3940 [Print] Ireland
• PMID: 6145121 (Publication Type: Journal Article)

Chemical References

• Aminobutyrates
• Dipeptides
• Pipecolic Acids
• Receptors, Cell Surface
• Receptors, Kainic Acid
• gamma-glutamylglycine
• 2,3-piperidinedicarboxylic acid
• 2-Amino-5-phosphonovalerate
• 2-amino-4-phosphonobutyric acid
• Valine
• Kainic Acid

Topics

• 2-Amino-5-phosphonovalerate
• Aminobutyrates (pharmacology)
• Animals
• Chickens (metabolism)
• Dipeptides (pharmacology)
• Kainic Acid (pharmacology)
• Photoreceptor Cells (physiology)
• Pipecolic Acids (pharmacology)
• Receptors, Cell Surface (metabolism)
• Receptors, Kainic Acid
• Retina (metabolism)
• Retinal Ganglion Cells (drug effects)
• Synaptic Transmission (drug effects)
• Valine (analogs & derivatives, pharmacology)