Abstract |
In the present study the effects of intracerebroventricularly [icv] administered somatostatin [linear and cyclic], somatostatin3-6, somatostatin7-10 and des AA1,2,4,5,12,13 [D-Trp8] somatostatin [ODT8-SS] were investigated on electroconvulsive shock [ECS]-induced retrograde amnesia in rats. The ECS significantly decreased the foot shock-induced avoidance latency, and thus caused retrograde amnesia. Somatostatin [linear and cyclic] in a dose of 0.6 nM had no action on the ECS-induced retrograde amnesia, while in doses of 3 nM and [cyclic only] 6 nM it significantly prevented it. Somatostatin3-6, somatostatin7-10 and ODT8-SS in doses of 0.6, 3 and 6 nM had no effect on the ECS-induced amnesia. These results indicate that the whole sequence of the original somatostatin molecule is needed to block the ECS-caused retrograde amnesia.
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Authors | L Vécsei, I Bollók, J Varga, B Penke, G Telegdy |
Journal | Neuropeptides
(Neuropeptides)
Vol. 4
Issue 2
Pg. 137-43
(Mar 1984)
ISSN: 0143-4179 [Print] Netherlands |
PMID | 6144072
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Amnesia
(physiopathology)
- Amnesia, Retrograde
(physiopathology)
- Animals
- Electroshock
- Humans
- Male
- Rats
- Somatostatin
(administration & dosage, pharmacology)
- Structure-Activity Relationship
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