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Intramuscular human interferon-beta injections in treatment of condylomata acuminata.

Abstract
A two-part study was done to assess the value of human fibroblast interferon (IFN-beta) in the treatment of condylomata acuminata. The first part was an open study of different IFN-beta preparations, which showed that intramuscular injection was the most suitable mode of administration of IFN-beta. In the double-blind placebo section 22 patients were given injections of 2 X 10(6) units IFN-beta or placebo for 10 consecutive days and followed up for 3 months. In 9 of the 11 in the IFN-beta group and 2 in the placebo group lesions disappeared from about 5 weeks after completion of the course of injections. After 3 months 8 of the non-responders were given a course of IFN-beta and all responded to treatment. None of those who had responded has had a recurrence, the disease-free period now being 12 months. Changes in (2'-5')oligo A synthetase levels in white blood cells confirm that intramuscular injections of IFN-beta produce a systemic response.
AuthorsA Schonfeld, S Nitke, A Schattner, D Wallach, M Crespi, T Hahn, H Levavi, O Yarden, J Shoham, T Doerner
JournalLancet (London, England) (Lancet) Vol. 1 Issue 8385 Pg. 1038-42 (May 12 1984) ISSN: 0140-6736 [Print] England
PMID6143975 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Interferon Type I
  • 2',5'-Oligoadenylate Synthetase
Topics
  • 2',5'-Oligoadenylate Synthetase (blood)
  • Adolescent
  • Adult
  • Animals
  • Clinical Trials as Topic
  • Condylomata Acuminata (therapy)
  • Double-Blind Method
  • Female
  • Genital Neoplasms, Female (therapy)
  • Genital Neoplasms, Male (therapy)
  • Humans
  • Injections, Intramuscular
  • Interferon Type I (administration & dosage)
  • Leukocytes (enzymology)
  • Male
  • Papillomaviridae (growth & development)
  • Random Allocation
  • Tumor Virus Infections (therapy)
  • Virus Replication (drug effects)

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