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Angiostrongylus cantonensis: paralysis due to avermectin B1a and ivermectin.

Abstract
Paralysis due to avermectin B1a and ivermectin of Angiostrongylus cantonensis was compared to that of phenylephrine (an alpha-adrenergic agonist) and strychnine (a cholinergic inhibitor). The paralyzing action of ivermectin (2.5 X 10(-9) g/ml) was inhibited by the single, simultaneous addition of picrotoxin (3 X 10(-5) M), whereas the effect of the drug (2.5 X 10(-7) g/ml) was reversed only when picrotoxin was given with cholinergic spasmogens such as pyrantel and eserine. Bicuculline (3 X 10(-5) M) had a similar antagonistic effect for picrotoxin, but bicuculline was less effective. The paralyzing action of avermectin B1a (3.6 X 10(-14) M, 3.0 X 10(-14) g/ml) was antagonized only when picrotoxin was given with cholinergic spasmogens such as pyrantel, eserine, and N-methylcytisine (N-MC), or alpha-adrenergic antagonists such as phentolamine and dibenamine. On the other hand, the paralyzing action of strychnine (3 X 10(-6) M) or phenylephrine (3 X 10(-5) M) was relatively uninfluenced by picrotoxin, but was antagonized by pyrantel and N-MC or dibenamine. These results suggest that a gabergic mechanism is involved in the paralyzing action of ivermectin, as well as avermectin B1a, in A. cantonensis.
AuthorsM Terada, A I Ishii, H Kino, M Sano
JournalExperimental parasitology (Exp Parasitol) Vol. 57 Issue 2 Pg. 149-57 (Apr 1984) ISSN: 0014-4894 [Print] United States
PMID6143682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic alpha-Antagonists
  • Alkaloids
  • Anthelmintics
  • Lactones
  • Quinolizines
  • Picrotoxin
  • Phenylephrine
  • Pyrantel
  • avermectin B(1)a
  • Ivermectin
  • Physostigmine
  • Strychnine
  • N-methylcytisine
  • Bicuculline
Topics
  • Adrenergic alpha-Antagonists (pharmacology)
  • Alkaloids (pharmacology)
  • Angiostrongylus (drug effects, physiology)
  • Animals
  • Anthelmintics (pharmacology)
  • Bicuculline (pharmacology)
  • Ivermectin
  • Lactones (pharmacology)
  • Metastrongyloidea (drug effects)
  • Movement (drug effects)
  • Muscle Contraction (drug effects)
  • Phenylephrine (pharmacology)
  • Physostigmine (pharmacology)
  • Picrotoxin (pharmacology)
  • Pyrantel (pharmacology)
  • Quinolizines
  • Strychnine (pharmacology)

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