Abstract |
Paralysis due to avermectin B1a and ivermectin of Angiostrongylus cantonensis was compared to that of phenylephrine (an alpha-adrenergic agonist) and strychnine (a cholinergic inhibitor). The paralyzing action of ivermectin (2.5 X 10(-9) g/ml) was inhibited by the single, simultaneous addition of picrotoxin (3 X 10(-5) M), whereas the effect of the drug (2.5 X 10(-7) g/ml) was reversed only when picrotoxin was given with cholinergic spasmogens such as pyrantel and eserine. Bicuculline (3 X 10(-5) M) had a similar antagonistic effect for picrotoxin, but bicuculline was less effective. The paralyzing action of avermectin B1a (3.6 X 10(-14) M, 3.0 X 10(-14) g/ml) was antagonized only when picrotoxin was given with cholinergic spasmogens such as pyrantel, eserine, and N-methylcytisine (N-MC), or alpha-adrenergic antagonists such as phentolamine and dibenamine. On the other hand, the paralyzing action of strychnine (3 X 10(-6) M) or phenylephrine (3 X 10(-5) M) was relatively uninfluenced by picrotoxin, but was antagonized by pyrantel and N-MC or dibenamine. These results suggest that a gabergic mechanism is involved in the paralyzing action of ivermectin, as well as avermectin B1a, in A. cantonensis.
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Authors | M Terada, A I Ishii, H Kino, M Sano |
Journal | Experimental parasitology
(Exp Parasitol)
Vol. 57
Issue 2
Pg. 149-57
(Apr 1984)
ISSN: 0014-4894 [Print] United States |
PMID | 6143682
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Antagonists
- Alkaloids
- Anthelmintics
- Lactones
- Quinolizines
- Picrotoxin
- Phenylephrine
- Pyrantel
- avermectin B(1)a
- Ivermectin
- Physostigmine
- Strychnine
- N-methylcytisine
- Bicuculline
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Topics |
- Adrenergic alpha-Antagonists
(pharmacology)
- Alkaloids
(pharmacology)
- Angiostrongylus
(drug effects, physiology)
- Animals
- Anthelmintics
(pharmacology)
- Bicuculline
(pharmacology)
- Ivermectin
- Lactones
(pharmacology)
- Metastrongyloidea
(drug effects)
- Movement
(drug effects)
- Muscle Contraction
(drug effects)
- Phenylephrine
(pharmacology)
- Physostigmine
(pharmacology)
- Picrotoxin
(pharmacology)
- Pyrantel
(pharmacology)
- Quinolizines
- Strychnine
(pharmacology)
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