Anxiolytic-like properties of fominoben.

Abstract

Fominoben, a centrally acting antitussive, has been shown recently to bind to the brain benzodiazepine binding site and to antagonize pentylenetetrazol-induced seizures. The present study reports the ability of fominoben to produce anti-anxiety effects analogous to diazepam in a mouse exploratory model for anxiolytics. This action of fominoben was blocked by Ro15-1788, a benzodiazepine receptor antagonist, implicating a brain benzodiazepine binding site in this anxiolytic action of fominoben.

• Authors: J N Crawley, L K Blumstein, F Baldino Jr
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 97 Issue 3-4 Pg. 277-81 (Jan 27 1984) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6142823 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Benzodiazepinones
• Morpholines
• Benzodiazepines
• Flumazenil
• Diazepam

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Benzodiazepines (antagonists & inhibitors)
• Benzodiazepinones (pharmacology)
• Diazepam (pharmacology)
• Flumazenil
• Male
• Mice
• Mice, Inbred C57BL
• Morpholines (pharmacology)